The Clinical and Translational Research Center of the Charles Drew University is an outpatient clinical facility that supports the quest for the knowledge and understanding of the diseases that disproportionately affect the minority populations in the Southwest area of Los Angeles. As a part of the mission of the University to conduct education, research and clinical services in the context of community engagement, the Center seeks and supports mutually beneficial collaborative partnerships with community service agencies. We support the care for the underserved populations by sharing educational and research resources that enhance the therapeutic and diagnostic capabilities of the health service agencies in the Southwest area of Los Angeles. We welcome innovative collaborative opportunities that deepen the understanding of minority health concerns and advance the development of solutions to health disparities.
Johnson, Holly, MPH
Role: CTRC Administrator
"Cardiovascular Disease (CVD) and related disorders remain the leading cause of death in the nation. Hypovitaminosis D has been linked not only to several cardiovascular (CV) risk factors including hypertension, diabetes, obesity but also to increased rates of CVD. Thus,hypovitaminosis D presents a common pathway for a select subgroup with a clustering of CV risk factors in a profile that is predominant among ethnic minorities. Indeed, hypovitaminosis D is highly prevalent with an estimated 55% of the US adult population having levels at or below 30 ng/ml, and over 80% of African Americans having suboptimal values. Thus, we propose a twelve week randomized double-blind, placebo controlled pilot trial to assess the effect on vascular function and CV risk factors of 100,000 IU Vitamin D3 given every 4 weeks to overweight, hypertensive African-Americans with hypovitaminosis D. To our knowledge, the proposed project is the first to assess the effect of 'high-dose' Vitamin D3 administration on vascular function.We believe this study is also the first to examine the impact at a molecular level of Vitamin D3 repletion on the key mediators of cardio-metabolic pathways in humans. If our study results support our working hypothesis, we will be positioned to propose a larger scale study to detect a therapeutic effect on more definitive, clinical cardiovascular endpoints across a more diverse population."
"Glutathione is a powerful protective substance found within every cell in the body. It has been shown that glutathione levels go down as a person gets older, which makes a person more likely to get heart disease, high blood sugar problems and different kind of cancers. N-Acetyl Cysteine is used as a dietary supplement. It has been reported to increase glutathione levels in the body. The diet supplement called ProImmune is also changed by the body into glutathione. Therefore, the purpose of this study is to find out the effect of ProImmune in healthy people. This study will also help to prove whether or not the ProImmune is able to improve the blood levels of glutathione in healthy people."
"EndoPAT is the leading medical device for noninvasive endothelial function assessment. It is FDA-cleared, CE-marked and used in preeminent clinical and research institutions, major epidemiological population-based studies (such as Framingham Heart Study), and pharmaceutical clinical phase studies in over 40 countries. Thousands of tests are performed every month."
"The MAC 5500 system offers a comprehensive suite of ECG interpretation and analysis programs. Its array of arrhythmia and chest pain tools allow you to address a wider range of disease management needs. Make more efficient treatment decisions and use invasive tests more judiciously."
"DEXA Scan is commonly used to assess body composition and changes in body composition. DEXA provides a three-component model of body composition: fat mass (FAT), fat-free soft tissue (FFST), and bone mineral content (BMC). Measures of bone mineral density (BMD) and percent body fat (%BF) are also obtained using fan-beam scanning."
"PWA is a computerized clinical assessment tool for measuring central blood pressure. The peripheral pressure pulse waveform contains information in addition to the maximum and minimum values (systolic and diastolic pressures) PWV measures the velocity of the blood pressure waveform between any two superficial artery sites. The velocity is dependent upon the stiffness of the artery along which the pulse is traveling. Values for both are displayed both graphically and numerically."
"Intima Media Thickness (IMT) U/S measures arterial thickening and provides the earliest evidence of atherosclerosis, or hardening of the arteries, the beginning stage of a disease process that leads to heart disease and stroke. Doctors can use this carotid intima media thickness (CIMT) measurement to calculate the age of the patient's arteries, which does not always match the patient's calendar age."
"24Hr ABPM monitoring provides a more accurate physiological assessment of blood pressure as compared to random blood pressure measurement obtained with the seated blood pressure method."
"Tanita's best-selling body composition analyzer offers the same measurements value as the TBF-410GS but in a portable design. Separate display head can be placed on a desktop in or out of the subject's view."
"YSI glucose and lactate analyzers have been recognized for standards of measurement in blood glucose and lactate for more than a quarter century. The YSI 2300 STAT measures glucose and lactate simultaneously in whole blood or plasma. Alternatively, configure the analyzer to measure glucose only or measure lactate only. The YSI 2300 is ideal for:
STAT Lab or Central Lab
Diabetes / Endocrinology Research
Human Performance Evaluation
Exercise / Athlete Evaluation
Cardiac / Pulmonary Rehabilitation
General Metabolic Research
Veterinary Medicine & Research
Pharmaceutical Quality Assurance"
"Process that involves the use of the centrifugal force for the separation of whole blood to obtain serum or plasma specimens. Ambient and refrigerated."
"The CDU CRC is primarily an outpatient facility consisting of eight beds. Although it is primarily an outpatient facility, the CRC can provide nursing and clerical staffing for 24-hour inpatient care required for certain studies through the use of scatter beds in the hospital itself.
The CRC is responsible for all nutritional services to patients in the CRC. This includes meal service to all inpatients and outpatients on the unit who are required to stay for three or more hours, as well as more detailed nutrition care and diet analysis when requested. Investigators working in the area of diet and metabolism, and who might thus need the specialized nutritional services offered by the CDU CRC, are similarly focused on the overall goal of eliminating health disparities in minority and underserved populations."
"Drug preparation, packaging, and labeling. Facilitating medication distribution, storage, security and documentation."
"The complete action or process of acquiring or obtaining drugs from an outside pharmaceutical company. More specifically, the action or process of purchasing, contracting, and negotiating directly with the source of supply."