eagle-i Charles Drew University of Medicine and ScienceCharles Drew University of Medicine and Science
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Effect of Vitamin D3 on Vascular Function

eagle-i ID

http://cdrewu.eagle-i.net/i/00000136-1d15-a68e-1a88-e81c80000000

Resource Type

  1. Parallel group study

Properties

  1. Intervention
    Vitamin D3 - Two 50,000 IU tablets given orally every 4 weeks
  2. Intervention
    Placebo (microcrystalline cellulose) - 2 tablets given orally every 4 weeks
  3. Resource Description
    "Cardiovascular Disease (CVD) and related disorders remain the leading cause of death in the nation. Hypovitaminosis D has been linked not only to several cardiovascular (CV) risk factors including hypertension, diabetes, obesity but also to increased rates of CVD. Thus,hypovitaminosis D presents a common pathway for a select subgroup with a clustering of CV risk factors in a profile that is predominant among ethnic minorities. Indeed, hypovitaminosis D is highly prevalent with an estimated 55% of the US adult population having levels at or below 30 ng/ml, and over 80% of African Americans having suboptimal values. Thus, we propose a twelve week randomized double-blind, placebo controlled pilot trial to assess the effect on vascular function and CV risk factors of 100,000 IU Vitamin D3 given every 4 weeks to overweight, hypertensive African-Americans with hypovitaminosis D. To our knowledge, the proposed project is the first to assess the effect of 'high-dose' Vitamin D3 administration on vascular function.We believe this study is also the first to examine the impact at a molecular level of Vitamin D3 repletion on the key mediators of cardio-metabolic pathways in humans. If our study results support our working hypothesis, we will be positioned to propose a larger scale study to detect a therapeutic effect on more definitive, clinical cardiovascular endpoints across a more diverse population."
  4. PI
    Norris, Keith, M.D., FACP
  5. Topic
    cardiovascular system disease
  6. Study Population
    Overweight African American adults with hypertension and low vitamin D levels
  7. Performed by
    Clinical and Translational Research Center
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    efleming (Erik Fleming)
  3. created
    2012-03-16T15:06:25.392-05:00
  4. creator
    efleming (Erik Fleming)
  5. modified
    2012-04-05T14:04:45.518-05:00

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